期刊
EXPERIMENTAL CELL RESEARCH
卷 388, 期 1, 页码 -出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2020.111824
关键词
Rho GTPases; Signaling complex; Lamellipodia; Filopodia; Invadopodia
资金
- Fundamental Research Funds for the Central Universities of Lanzhou University [lzujbky-2016k16]
- Natural Science Foundation of Gansu Province [18JR3RA306]
Cell migration and invasion play an important role in the development of cancer. Cell migration is associated with several specific actin filament-based structures, including lamellipodia, filopodia, invadopodia and blebs, and with cell-cell adhesion, cell-extracellular matrix adhesion. Migration occurs via different modes, human epithelial cancer cells mainly migrate collectively, while in vivo imaging studies in laboratory animals have found that most cells migrate as single cells. Rho GTPases play an important role in the process of cell migration, and several Rho GTPase-related signaling complexes are also involved. However, the exact mechanism by which these signaling complexes act remains unclear. This paper reviews how Rho GTPases and related signaling complexes interact with other proteins, how their expression is regulated, how tumor microenvironment-related factors play a role in invasion and metastasis, and the mechanism of these complex signaling networks in cell migration and invasion.
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