期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 48, 期 2, 页码 74-82出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000219
关键词
treadmill; wheel running; Cre-lox; GnRH; POMC; knockout mice; bHLH transcription factor
资金
- Virginia Tech
Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop-helix transcription factor NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise.
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