期刊
EUROPEAN RADIOLOGY
卷 30, 期 4, 页码 1969-1979出版社
SPRINGER
DOI: 10.1007/s00330-019-06558-1
关键词
Ultrasonography; Machine learning; Rectal neoplasms
资金
- National Nature Science Foundation of China [81701719 and 81701701] Funding Source: Medline
Objective To develop a machine learning-based ultrasound (US) radiomics model for predicting tumour deposits (TDs) preoperatively. Methods From December 2015 to December 2017, 127 patients with rectal cancer were prospectively enrolled and divided into training and validation sets. Endorectal ultrasound (ERUS) and shear-wave elastography (SWE) examinations were conducted for each patient. A total of 4176 US radiomics features were extracted for each patient. After the reduction and selection of US radiomics features , a predictive model using an artificial neural network (ANN) was constructed in the training set. Furthermore, two models (one incorporating clinical information and one based on MRI radiomics) were developed. These models were validated by assessing their diagnostic performance and comparing the areas under the curve (AUCs) in the validation set. Results The training and validation sets included 29 (33.3%) and 11 (27.5%) patients with TDs, respectively. A US radiomics ANN model was constructed. The model for predicting TDs showed an accuracy of 75.0% in the validation cohort. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and AUC were 72.7%, 75.9%, 53.3%, 88.0% and 0.743, respectively. For the model incorporating clinical information, the AUC improved to 0.795. Although the AUC of the US radiomics model was improved compared with that of the MRI radiomics model (0.916 vs. 0.872) in the 90 patients with both ultrasound and MRI data (which included both the training and validation sets), the difference was nonsignificant (p = 0.384). Conclusions US radiomics may be a potential model to accurately predict TDs before therapy.
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