Endocrine therapy for hormone treatment-naive advanced breast cancerf

A proportion of patients with hormone receptor-positive locally advanced or metastatic breast cancer will not have received prior endocrine therapy. However, there are limited clinical data specifically in these patients. We conducted a review of randomized phase II and III clinical studies of anastrozole, letrozole, exemestane, palbociclib, and fulvestrant to determine the evidence base supporting use of specific endocrine therapies in this patient population. From our findings, there is a paucity of clinical studies in patients with endocrine therapy-naive disease; however, it appears that first-line treatment effects are consistent between patients who have and have not received prior endocrine treatment. (C) 2016 The Authors. Published by Elsevier Ltd.