期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 124, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2020.108827
关键词
Pancreas; Sonoelastography; Elasticity; Shear wave velocity; Type 2 diabetes; Diabetic microangiopathy
资金
- National Natural Science Foundation of China [81201094, 31271235]
- Science and Technology Department of Jilin Province [20130413005GH, 20170414042GH]
- Finance Department of Jilin Province [2019SCZ060]
Purpose: The aim of this study was to noninvasively explore pancreatic morphological and mechanical changes in diabetic patients with or without microangiopathy and to investigate the clinical correlations of pancreatic stiffness or size with diabetic microangiopathy. Methods: A total of 213 type 2 diabetic patients with / without microangiopathy (91/122) were prospectively enrolled. Microangiopathy included diabetic retinopathy, diabetic nephropathy and diabetic peripheral neuropathy. Each subject underwent pancreatic ultrasonography and elastography. The shear wave velocity (SWV) and thickness of the head, body and tail were measured and compared. Receiver operating characteristic (ROC) curves was performed in the diagnosis of microangiopathy. Risk factors of the occurrence of more microvascular complications were explored. Results: The SWV in pancreas increased significantly in patients with microangiopathy (P < 0.01) while the thickness was similar in all patients. The area under ROC curve for the SWV in pancreatic body was greatest (0.747) and the sensitivity, specificity were 73.0, 70.9 %. There was a significant shift towards the occurrence of more microvascular complications for patients with increasing of the SWV in pancreatic body (OR 39.25), long duration of diabetes (OR 1.077), aging (OR 1.039) and elevation of microalbuminuria (OR 1.004). Conclusions: The SWV in pancreatic body was significantly high in diabetic patients with microangiopathy and was prominently correlated with the number of microvascular complications. The SWV in pancreatic body may be considered as a potential marker for diabetic microangiopathy and its occurrence.
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