期刊
EUROPEAN JOURNAL OF PEDIATRICS
卷 179, 期 8, 页码 1309-1313出版社
SPRINGER
DOI: 10.1007/s00431-020-03572-0
关键词
Less invasive surfactant; LISA - CPAP; Premature infants; Outcome
类别
资金
- Projekt DEAL
- German Ministry for Education and Research (BMBF) [01ER0805, 01ER1501]
Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:center dot LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:center dot Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.
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