期刊
EUROPEAN JOURNAL OF PEDIATRICS
卷 179, 期 5, 页码 835-838出版社
SPRINGER
DOI: 10.1007/s00431-019-03550-1
关键词
Cystic fibrosis; Kidney; Osmoregulation
类别
资金
- Russian Science Foundation, Saint-Petersburg, Russia [18-15-00358]
- Russian Science Foundation [18-15-00358] Funding Source: Russian Science Foundation
Hyponatremia is not rare in cystic fibrosis and might be due to several mechanisms. An endocrine and renal imbalance in water and salt homeostasis was suggested. To address this hypothesis, we assessed the urinary concentrating and diluting ability in 12 cystic fibrosis patients (6 females, 6 males) and in two control groups: 14 children with pneumonia (9 females, 5 males) and in 13 healthy children (9 females, 4 males). Renal concentrating ability was evaluated following overnight water deprivation. Urine osmolality was not significantly different between groups. Renal diluting ability was assessed by means of a water-load test. This provoked a decrease in urine osmolality, as well as an increase in diuresis and solute-free water excretion. These changes were comparable among groups. Conclusion: Children with cystic fibrosis show a preserved renal concentrating and diluting capacity. A generalized endocrine and renal imbalance in water and salt homeostasis therefore appears unlikely.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据