Copper-Catalyzed Direct Carbamoylation of Quinoxalin-2(1H)-ones with Hydrazinecarboxamides Under Mild Conditions

A direct C-H bond carbamoylation of quinoxalin-2(1H)-ones with hydrazinecarboxamides has been developed. This reaction provides a series of 3-carbamoylquinoxalin-2(1H)-one derivatives in moderate to good yields under mild conditions with a broad range of substrates and functional group tolerance. The present methodology affords a convenient and practical access to pharmaceutically active 3-carbamoylquinoxalin-2(1H)-one derivatives.