期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2020, 期 8, 页码 1006-1014出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201901825
关键词
Hydroxylamine-O-sulfonic acid; Isoquinoline; Redox-neutral; Rhodium catalysis; C-H activation
资金
- SERB [EMRII/2017/001475]
- DAE
- DST-INSPIRE
- CSIR
A new application of hydroxylamine-O-sulfonic acid (HOSA) has been discovered whereby aromatic ketones react with HOSA and alkynes to form isoquinolines in the presence of a Rh-III catalyst. This C-H/N-O annulation methodology gives excellent yields even without any silver additive, acid/base or metal oxidant. This is the first report wherein a directing group is simultaneously forming in situ, acting as acid additive, and also as an internal oxidant.
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