期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 183, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.111700
关键词
1,2,3-Triazole; Hybrid molecules; Anticancer; Action mechanism; Structure-activity relationship
资金
- Guizhou Domestic First-class Construction Project (Chinese Materia Medical) [GNYL [2017] 008-7]
- Guizhou University of Traditional Chinese Medicine
Anticancer agents are critical for the cancer treatment, but side effects and the drug resistance associated with the currently used anticancer agents create an urgent need to explore novel drugs with low side effects and high efficacy. 1,2,3-Triazole is privileged building block in the discovery of new anticancer agents, and some of its derivatives have already been applied in clinics or under clinical trials for fighting against cancers. Hybrid molecules occupy an important position in cancer control, and hybridization of 1,2,3-triazole framework with other anticancer pharmacophores may provide valuable therapeutic intervention for the treatment of cancer, especially drug-resistant cancer. This review emphasizes the recent advances in 1,2,3-triazole-containing hybrids with anticancer potential, covering articles published between 2015 and 2019, and the structure-activity relationships, together with mechanisms of action are also discussed. (C) 2019 Elsevier Masson SAS. All rights reserved.
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