期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 187, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.111982
关键词
Near infrared fluorescence dye probes; Amyloid-beta plaques; Tau fibrils; Alzheimer's disease
资金
- National Natural Science Foundation of China [81671069]
- Open Research Project of Jiangsu Key Laboratory of Immunity and Metabolism [JSKIM201802]
- Open Research Project of Jiangsu Key Laboratory of Brain Disease Bioinformation [JSBL201802]
- Project of Xuzhou Science and Technology Plan [KC16SW164]
Alzheimer's disease (AD) is characterized by progressive decrease in cognitive abilities, language impairment and irreversible memory loss. Amyloid-beta (A beta) and tau deposits are essential as the major factors involved in the pathogenesis of AD. Unfortunately, anti-Alzheimer's disease agents currently available are not potent enough to reverse the cause of the disease. Interestingly, near infrared fluorescence (NIRF) dyes have been marked as promising tools in analytical researches and are often adopted as molecular probes to monitor and diagnose AD, in vitro or in vivo. Compared with other imaging techniques, such as positron emission tomography (PET), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT), NIRF dye probes have been applied in AD pre-clinical trials and have gained rapid benefits, in view of their advantages including real time imaging, biocompatibility, high selectivity and sensitivity, high spatiotemporal resolution, and easy data analysis. This work reviews the developmental design of typical NIRF dye probes in monitoring A beta s and tau species in the brain of AD model mice and patients. (C) 2019 Elsevier Masson SAS. All rights reserved.
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