4.5 Review

Crossroads between immune responses and physiological regulation: Metabolic control of resistance versus tolerance against disease

期刊

EUROPEAN JOURNAL OF IMMUNOLOGY
卷 50, 期 4, 页码 484-489

出版社

WILEY
DOI: 10.1002/eji.201948159

关键词

Disease tolerance; Immunity; Infection; Tissue metabolism

资金

  1. Associazione Italiana Ricerca sul Cancro [1556] Funding Source: Medline
  2. Progetti di Ricerca di Interesse Nazionale [2015YYKPNN_003, 20174T7NXL_004] Funding Source: Medline

向作者/读者索取更多资源

If a threat cannot be avoided, the organism has two defense options: it can try to eliminate the threatening agent or boost physiological mechanisms to tolerate the challenge and its consequences. Both strategies can be (and usually are) used at the same time. Fighting an infection, for instance, requires mounting immune responses to control pathogen burden as well as physiologic adaptations to tolerate stress and damage. Thus, the two strategies are connected and interdependent. We are starting to understand how the regulation of host metabolic physiology during disease impacts both the ability to resist pathogens' burden and tolerate parenchymal tissue functional damage. Here, we review a number of recent publications that have begun to shed light on the physiological and immunological mechanisms that coordinate host defense and metabolic processes. In particular, we will cover the areas of energetic control, substrates utilization, and the regulatory signals that promote infectious disease tolerance.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据