期刊
EUROPEAN HEART JOURNAL
卷 41, 期 31, 页码 2974-+出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehz961
关键词
Inflamm-ageing; Vascular ageing; Inflammation; Endothelial dysfunction; Cardiovascular disease
资金
- Swiss National Science Foundation [310030_175546]
- Swiss Heart Foundation
- Alfred and Annemarie von Sick Grants for Translational and Clinical Research Cardiology and Oncology
- Sheikh Khalifa's Foundation Ass. Professorship at the Faculty of Medicine, University of Zurich
- National Heart, Lung, and Blood Institute [R01HL080472]
- American Heart Association [18CSA34080399]
- RRM Charitable Fund
- Foundation for Cardiovascular Research-Zurich Heart House
- Swiss National Science Foundation (SNF) [310030_175546] Funding Source: Swiss National Science Foundation (SNF)
The ongoing worldwide increase in life expectancy portends a rising prevalence of age-related cardiovascular (CV) diseases in the coming decades that demands a deeper understanding of their molecular mechanisms. Inflammation has recently emerged as an important contributor for CV disease development. Indeed, a state of chronic sterile low-grade inflammation characterizes older organisms (also known as inflamm-ageing) and participates pivotally in the development of frailty, disability, and most chronic degenerative diseases including age-related CV and cerebrovascular afflictions. Due to chronic activation of inflammasomes and to reduced endogenous anti-inflammatory mechanisms, inflamm-ageing contributes to the activation of leucocytes, endothelial, and vascular smooth muscle cells, thus accelerating vascular ageing and atherosclerosis. Furthermore, inflamm-ageing promotes the development of catastrophic athero-thrombotic complications by enhancing platelet reactivity and predisposing to plaque rupture and erosion. Thus, inflamm-ageing and its contributors or molecular mediators might furnish targets for novel therapeutic strategies that could promote healthy ageing and conserve resources for health care systems worldwide. Here, we discuss recent findings in the pathophysiology of inflamm-ageing, the impact of these processes on the development of age-related CV diseases, results from clinical trials targeting its components and the potential implementation of these advances into daily clinical practice.
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