期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 74, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.etap.2019.103303
关键词
Nanomaterial; Iron; Nickel; Zinc; Pulmonary; Metal oxides
资金
- EU FP7 NANODEVICE project [CP-IP 211464-2]
- Danish Centre for Nanosafety 1 (Danish Working Environment Research Fund) [20110092173-3]
- Danish Centre for Nanosafety 2
- EU Horizon 2020 project SmartNanoTox [686098]
Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 mu g by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation neutrophil influx into bronchoalveolar lavage (BAL) fluid - occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.
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