4.7 Article

Dynamic growth metrics for examining prenatal exposure impacts on child growth trajectories: Application to perfluorooctanoic acid (PFOA) and postnatal weight gain

期刊

ENVIRONMENTAL RESEARCH
卷 182, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2019.109044

关键词

Child growth trajectories; Growth velocity; Prenatal PFOA exposure

资金

  1. EDC-MixRisk European Union's Horizon 2020 Research and Innovation Programme [634880]
  2. National Institute of Environmental Health Sciences [PRIME R01ES028811-01]
  3. H2020 Societal Challenges Programme [634880] Funding Source: H2020 Societal Challenges Programme

向作者/读者索取更多资源

Background: Epidemiologic studies investigating prenatal exposures in relation to growth typically rely on cumulative growth measures such as weight or BMI. However, less is known about how prenatal exposure may impact other aspects of growth dynamics, including timing and velocity. Objectives: To describe and apply a nonlinear growth model previously used in other health science fields to characterize postnatal growth trajectories for use in environmental epidemiology studies. Methods: We used a double logistic function to model child weight trajectories from birth to 5.5 years using data from the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study. From this, we approximated several infant growth metrics: 1) duration of time needed to complete 90% of the infant growth spurt (Delta t(1)), 2) the maximum growth rate in infancy or infant peak growth velocity (PGV), 3) the age at infant PGV (delta(1)), a measure of growth tempo, and 4) the weight plateau at the end of the infant growth spurt (alpha(1)). We assessed these metrics in relation to prenatal perfluorooctanoic acid (PFOA) exposure among 1334 mother-child pairs, and differences between boys and girls. Results: Average estimated infant PGV and its timing (delta(1)) were 0.68 kg/month and 3.4 months, respectively. Mean infant growth spurt duration (Delta t(1)) was 13 months, ending at an average weight plateau (alpha(1)) of 8.2 kg. Higher prenatal PFOA concentrations were related to a longer duration of infant growth (Delta t(1): 0.06; 95% CI = 0.01, 0.11). PGV was not impacted, but higher prenatal PFOA concentrations were significantly related to delayed infant PGV (delta(1) : 0.58; 95% CI = 0.17, 0.99) and a higher post-spurt weight plateau (alpha(1): 0.81; 95% CI = 0.21, 1.41). After adjusting for false discovery, results were only significant for delta(1) and alpha(1). We observed a significant interaction by sex for the association with delta(1), and stratified analyses revealed the association was only significant among girls. Conclusion: Model-derived growth metrics were consistent with published growth standards. This novel application of nonlinear growth modeling enabled detection of altered infant growth dynamics in relation to prenatal PFOA exposure. Our results may help describe how PFOA yields lower birthweights, but higher weight later in childhood. Future applications may characterize adolescent growth or additional metrics of biological interest.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据