期刊
ENVIRONMENTAL HEALTH
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12940-020-0562-7
关键词
Human exposure; beta-Hexachlorocyclohexane; beta-HCH; Contamination; POPs; Chemical wastes
资金
- Lazio Region
Background Hexachlorocyclohexane is a synthetic chemical with several isomers, including beta-Hexachlorocyclohexane (beta-HCH). In 2005, a large contamination of crude milk from some bovine farms along the Sacco River (Central Italy) was detected; it was related to the illegal disposal of large quantities of processing waste by a chemical industry of the area. A biomonitoring study, conducted in 2007 on a sample of the residing population, found high values of beta-HCH in people living close to the river. These results led to the establishment of a clinical and epidemiological surveillance program on all the exposed population. The aim of the study was to evaluate the determinants of beta-HCH blood levels in people living within 1 Km of the Sacco River, focusing on the role of specific foods, body mass index and risk factors not yet identified. Methods The program involved all people living within 1 km of the river. A descriptive analysis of beta-HCH blood levels was done in relation to the potential determinants including specific foods. Regression analysis was used to study the association between potential determinants and (natural log) beta-HCH haematic concentration. The results were expressed as geometric mean ratios (GMR). To take into account similarities within the families we adjusted for family clustering. Results A total of 602 subjects (87.2%) agreed to participate in the surveillance. The beta-HCH geometric mean serum concentration was 72 ng/g lipid. The regression analysis showed that being female (GMR: 1.32, 95%CI: 1.14-1.53), elderly (GMR(> 70yy): 10.04, 95%CI: 6.65-15.15), obese (GMR: 1.63, 95%CI: 1.28-2.08), eating food of local/own production (GMR 1.47, 95%CI: 1.15-1.88) and using water from private wells (GMR(drink):1.47, 95%CI: 1.00-2.14 and GMR(wash): 1.48, 95%CI: 1.17-1.87) were associated with higher beta-HCH values. There was inverse association with breastfeeding (GMR: 0.64, 95%CI: 0.47-0.86). The focus on specific foods showed that the most important factors were eggs and beef. Conclusions The study indicated a greater contamination for older people, and those drinking and washing with water from private wells and consuming locally produced food, especially eggs and beef.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据