期刊
BRAIN RESEARCH BULLETIN
卷 122, 期 -, 页码 1-11出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2015.12.003
关键词
Alzheimer's disease; Mouse model; Genetic model; Preclinical model; Translational assays; Biomarkers; Genomics; Neuroinflammation
资金
- T32 training grant
- NIH [RF1 AG051496]
- Jane B. Cook Foundation
Genetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspects of the biology of the disease, but have had limited success in translating these findings to the clinic. In this review, we discuss the benefits and limitations of existing genetic models and recent advances in technologies (including high throughput sequencing and genome editing) that promise more predictive models. We summarize widely used biomarkers and behavioral tests for mouse models of AD and highlight best practices that will maximize translatability of preclinical findings. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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