期刊
BRAIN RESEARCH BULLETIN
卷 126, 期 -, 页码 311-323出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2016.06.004
关键词
Actin cytoskeleton; Tropomyosin; Neurite outgrowth; Central nervous system; Regeneration
资金
- Australian National Health and Medical Research Council (NHMRC) [APP1083209]
Regulation of the actin cytoskeleton is dependent on a plethora of actin-associated proteins in all eukaryotic cells. The family of tropomyosins plays a key role in controlling the function of several of these actin-associated proteins and their access to actin filaments. In order to understand the regulation of the actin cytoskeleton in highly dynamic subcellular compartments of neurons such as growth cones of developing neurons and the synaptic compartment of mature neurons, it is pivotal to decipher the functional role of tropomyosins in the nervous system. In this review, we will discuss the current understanding and recent findings on the regulation of the actin cytoskeleton by tropomyosins and potential implication that this has for the dysregulation of the actin cytoskeleton in neurological diseases. (C) 2016 Elsevier Inc. All rights reserved.
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