期刊
EMBO JOURNAL
卷 39, 期 5, 页码 -出版社
WILEY
DOI: 10.15252/embj.2019102783
关键词
actin cytoskeleton; immunological synapse; symmetry breaking; synapse mechanics; T-cell migration
资金
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation
- Koch Institute from the National Cancer Institute [P30-CA14051]
- Ragon Institute of MGH, MIT, and Harvard
- National Institutes of Health [AI43542]
- Wellcome Trust [PRF 100262]
- Yale University
- NIH [5R01AI100315]
When migratory T cells encounter antigen-presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are critical for T-cell immunity. While the cellular processes underlying synapse formation have been well characterized, those that maintain the symmetry, and thereby the stability of the synapse, remain unknown. Here we identify an antigen-triggered mechanism that actively promotes T-cell synapse symmetry by generating cytoskeletal tension in the plane of the synapse through focal nucleation of actin via Wiskott-Aldrich syndrome protein (WASP), and contraction of the resultant actin filaments by myosin II. Following T-cell activation, WASP is degraded, leading to cytoskeletal unraveling and tension decay, which result in synapse breaking. Thus, our study identifies and characterizes a mechanical program within otherwise highly motile T cells that sustains the symmetry and stability of the T cell-APC synaptic contact.
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