期刊
BRAIN RESEARCH
卷 1638, 期 -, 页码 116-128出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2015.08.013
关键词
NG2; Polydendrocyte; Oligodendrocyte; Cell fate; Lineage; Myelin
资金
- NIH [R01 NS073425, R01 NS074870]
- National Multiple Sclerosis Society [RG4579]
NG2 cells represent a fourth major glial cell population in the mammalian central nervous system (CNS). They arise from discrete germinal zones in mid-gestation embryos and expand to occupy the entire CNS parenchyma. Genetic fate mapping studies have shown that oligodendrocytes and a subpopulation of ventral protoplasmic astrocytes arise from NG2 cells. This review describes recent findings on the fate and fate potential of NG2 cells under physiological and pathological conditions. We discuss age-dependent changes in the fate and fate potential of NG2 cells and possible mechanisms that could be involved in restricting their oligodendrocyte differentiation or fate plasticity. This article is part of a Special Issue entitled SI:NG2-glia(Invitedonly). (C) 2015 Elsevier B.V. All rights reserved.
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