期刊
BRAIN RESEARCH
卷 1647, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2016.02.050
关键词
RNA-binding protein; RNA processing; Development; Neurodegenerative disease; Protein aggregate; Protein mis-regulation
资金
- Muscular Dystrophy Association [MDA276796]
- NIH [R01 HL045565, R01 AR45653, R01 AR060733]
RNA-binding protein activities are highly regulated through protein levels, intracellular localization, and post-translation modifications. During development, mRNA processing of specific gene sets is regulated through manipulation of functional RNA-binding protein activities. The impact of altered RNA-binding protein activities also affects human diseases in which there are either a gain-of-function or loss-of-function causes pathogenesis. We will discuss RNA-binding proteins and their normal developmental RNA metabolism and contrast how their function is disrupted in disease. This article is part of a Special Issue entitled SI:RNA Metabolism in Disease. (C) 2016 Elsevier B.V. All rights reserved.
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