期刊
DYES AND PIGMENTS
卷 177, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2020.108310
关键词
Fluorescent probe; Hypochlorous acid; 4-Hydroxy-1,8-naphthalimide; P-methylaminophenylether; Bioimaging
资金
- Shandong Provincial Natural Science Foundation [ZR2017MB014]
- National Natural Science Foundation of China [21777053, 21607053]
- Project of Shandong Province Higher Educational Science and Technology Support Program for Young Innovation [2019KJD005]
As one of the reactive oxygen species (ROS), hypochlorous acid (HOCl) plays a key role in the pathogenesis of a range of diseases. The detection of HOCl has been a hot research topic. Herein, this paper proposes a new conjugate of 4-hydroxy-1,8-naphthalimide and p-methylaminophenylether as fluorescent probe HNPE with simple synthesis and excellent performances to detect HOCl. The probe has a good linear relationship with HOCl (0-1 mu M), and its detection limit is 6.56 nM. Moreover, this probe has good selectivity, which can distinguish HOCl from other common analytes. Importantly, the probe HNPE has some achievements in HOCl imaging of living cells and zebrafish. Hence, the probe HNPE is competent as a tool to visualize HOCl in biosystems.
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