期刊
DRUG DEVELOPMENT RESEARCH
卷 81, 期 2, 页码 194-205出版社
WILEY
DOI: 10.1002/ddr.21643
关键词
Alzheimer's; cholesterol; diabetes; insulin resistance; oxidized lipids
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [5T32DK007646-27]
Diabetes disrupts organs throughout the body including the brain. Evidence suggests diabetes is a risk factor for Alzheimer's disease (AD) and neurodegeneration. In this review, we focus on understanding how diabetes contributes to the progression of neurodegeneration by influencing several aspects of the disease process. We emphasize the potential roles of brain insulin resistance, as well as cholesterol and lipid disruption, as factors which worsen AD.
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