期刊
DRUG DELIVERY
卷 27, 期 1, 页码 334-343出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2020.1724210
关键词
Enrofloxacin; 2-hydroxypropyl-beta-cyclodextrin; inclusion complex; preparation; pharmaceutical properties
Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier. It forms inclusion complexes with its drug substrates and improves their physiochemical and pharmacokinetic properties. Enrofloxacin was also found to form a stable inclusion complex with HP-beta-CD and different research groups have shown improved solubility for enrofloxacin by 32.5%, 9.25 and 165-fold. Our own efforts in this direction resulted in manifold improvement (916-fold) in its solubility compared to the previous studies. It was further shown that pharmaceutical properties, absorption and bioavailability, of enrofloxacin have also been significantly improved by complexation with HP-beta-CD.
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