期刊
DOSE-RESPONSE
卷 18, 期 1, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1559325820902338
关键词
radon hot springs; peripheral blood; lymphocyte subsets; low dose; hormesis
资金
- National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention
Objective: To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs. Methods: Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3(+), CD4(+)CD8(-), CD4(-)CD8(+), CD4(+)/CD8(+), and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer. Results: In the radon group, the numbers of CD3(+) (Z = -0.140, P > .05) and CD4(+)CD8(-) (Z = -0.964, P > .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4(-)CD8(+) (t = -2.141, P < .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4(+)/CD8(+) (t = -2.201, P < .05) and TCR/CD3 (t = 2.047, P < .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# (t = -0.485, P > .05) and LYMPH% (Z = -0.835, P > .05) showed no significant change. Conclusion: Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions.
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