期刊
DNA AND CELL BIOLOGY
卷 39, 期 5, 页码 738-746出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2019.5284
关键词
depression; bone metabolism; signaling molecules; mechanism; review
资金
- Youth Innovation Research Project of Sichuan Medical Association, China [Q16080]
- Key Project of Science and Technology Bureau, Luzhou, China [2017-S-41(1/7)]
Increasing evidence indicates that depression affects bone metabolism to some extent, but the specific mechanisms are still unclear. Numerous studies have confirmed that a variety of signaling molecules are involved in depression's impact on fracture healing, including serum monoamine neurotransmitters, cytokines, inflammatory markers, growth factors, and metabolites. This article comprehensively discusses the effects of depression-associated signaling molecules on bone metabolism and their underlying mechanisms to provide a basis for early preventive intervention for delayed fracture healing in patients with depression.
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