期刊
DIFFERENTIATION
卷 112, 期 -, 页码 10-16出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.diff.2019.11.002
关键词
Idiopathic pulmonary fibrosis; Lung resident mesenchymal stem cells; Myofibroblast differentiation; miRNA/mRNA integrated analysis; Kruppel-like factor 4
资金
- National Natural Science Foundation of China [81570059]
- Natural Science Foundation of Jiangsu Province of China [BK20151398]
Idiopathic pulmonary fibrosis (IPF) is a serious lung disease that involved the myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSCs). However, the specific molecular mechanisms of myofibroblast differentiation of LR-MSCs still remain a mystery. In this study, a comprehensive analysis of miRNAs and mRNAs changes in LR-MSCs treated with TGF-beta 1 was performed. Through computational approaches, the pivotal roles of differentially expressed miRNAs that were associated with tight junction, pathways in cancer, focal adhesion, and cytokine-cytokine receptor interaction were shown. Kruppel-like factor 4 (Klf4) and inhibitor of growth family, member 5 (Ing5) may be the targets for the therapy of pulmonary fibrosis by inhibiting myofibroblast differentiation of LR-MSCs and EMT. Collectively, a molecular paradigm for understanding myofibroblast differentiation of LR-MSCs in IPF was provided by the integrated miRNA/mRNA analyses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据