Highly facilitated synthesis of phenyl(tetramethyl)acridinedione pharmaceuticals by a magnetized nanoscale catalytic system, constructed of GO, Fe3O4 and creatine

Here, an efficient heterogeneous catalytic system, made of graphene oxide (GO) nano-sheets, iron oxide nano-particles (Fe3O4 NPs), and creatine (CR), is presented. Firstly, this novel designed catalytic system (GO/CR-Fe3O4) has been fabricated via a convenience method and magnetized via an in situ process. Then, it has been suitably applied for catalyzing the synthesis of 9-phenyl-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-acridine-1,8(2H,5H)-dione (PTAD) derivatives, as one of the most important family of pharmaceutical compounds. As the first and foremost advantage of this catalytic system, this can be referred that the GO/CR-Fe3O4 NPs are magnetically separated from the reaction mixture through their high paramagnetic behavior. In fact, the Fe3O4 NPs that are responsible for the magnetic property, are well intercalated between the GO's nano-sheets during the fabrication process. Electron microscopy (EM) has clearly disclosed this effective structure of the produced nanocomposite. Then, the substantial catalytic performance of this system for facilitating the PTAD synthesis is shown. In this work, this is exhibited that high reaction yields (98%) are obtained during short reaction times (10 min), through using a partial amount of nanocatalyst (0.03 g). Additionally, the catalysis reusability is also investigated after a five-time running the catalytic process.