期刊
DIABETES-METABOLISM RESEARCH AND REVIEWS
卷 36, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/dmrr.3286
关键词
diabetic neuropathy; painful diabetic neuropathy; diabetic foot ulceration; type 2 diabetes mellitus
资金
- Pfizer Gulf FZ LLC [W1230787]
- Qatar National Research Fund [BMRP-5726113101]
Aims Diabetic neuropathy (DN) is a Cinderella complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk of diabetic foot ulceration (DFU) is a major concern. We have determined the prevalence of DN and its risk factors, DFU, and those at risk of DFU in patients with type 2 diabetes mellitus (T2DM) in secondary care in Qatar. Materials and methods Adults with T2DM were randomly selected from the two National Diabetes Centers in Qatar. DN was defined by the presence of neuropathic symptoms and a vibration perception threshold (VPT) >= 15 V. Participants with a VPT >= 25 V were categorized as high risk for DFU. Painful DN was defined by a DN4 score >= 4. Logistic regression analysis was used to identify predictors of DN. Results In 1082 adults with T2DM (age 54 +/- 11 years, duration of diabetes 10.0 +/- 7.7 years, 60.6% males), the prevalence of DN was 23.0% (95% CI, 20.5%-25.5%) of whom 33.7% (95% CI, 27.9%-39.6%) were at high risk of DFU, and 6.3% had DFU; 82.0% of the patients with DN were previously undiagnosed. The prevalence of DN increased with age and duration of diabetes and was associated with poor glycaemic control (HbA(1c) >= 9%) AOR = 2.1 (95% CI, 1.3-3.2), hyperlipidaemia AOR = 2.7 (95% CI, 1.5-5.0), and hypertension AOR = 2.0 (95% CI, 1.2-3.4). Conclusions Despite DN affecting 23% of adults with T2DM, 82% had not been previously diagnosed with one-third at high risk for DFU. This argues for annual screening and identification of patients with DN. Furthermore, we identify hyperglycaemia, hyperlipidaemia, and hypertension as predictors of DN.
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