期刊
DIABETES
卷 69, 期 4, 页码 550-558出版社
AMER DIABETES ASSOC
DOI: 10.2337/dbi19-0002
关键词
-
资金
- Diabetes Research Institute Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [R56DK084321, R01DK084321, R01DK111538, R01DK113093, U01DK120456, R33ES025673, R21ES025673]
- Leona M. and Harry B. Helmsley Charitable Trust [G-2018PG-T1D034, G-1912-03552]
Secretion of glucagon from the pancreatic alpha -cells is conventionally seen as the first and most important defense against hypoglycemia. Recent findings, however, show that alpha -cell signals stimulate insulin secretion from the neighboring beta -cell. This article focuses on these seemingly counterintuitive local actions of alpha -cells and describes how they impact islet biology and glucose metabolism. It is mostly based on studies published in the last decade on the physiology of alpha -cells in human islets and incorporates results from rodents where appropriate. As this and the accompanying articles show, the emerging picture of alpha -cell function is one of increased complexity that needs to be considered when developing new therapies aimed at promoting islet function in the context of diabetes.
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