期刊
DEVELOPMENTAL CELL
卷 52, 期 3, 页码 261-275出版社
CELL PRESS
DOI: 10.1016/j.devcel.2020.01.027
关键词
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资金
- Pediatric Hydrocephalus Foundation
- Hydrocephalus Association
- NIH [R01 NS088566, RF1 DA048790]
- New York Stem Cell Foundation
- National Institute on Drug Abuse of the National Institutes of Health [RF1 DA048790]
We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS component with dynamic and diverse roles emerging in parallel with the developing CNS. This review examines the current understanding about early CSF and its maturation and roles during CNS development and discusses open questions in the field. We focus on developmental changes in the ventricular system and CSF sources (including neural progenitors and choroid plexus). We also discuss concepts related to the development of fluid dynamics including flow, perivascular transport, drainage, and barriers.
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