期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 62, 期 1, 页码 4-14出版社
WILEY
DOI: 10.1111/dgd.12644
关键词
gene regulation; Notch; signalling; transcription
资金
- Medical Research Council [MR/L007177/1]
- Wellcome Trust [109144/Z/15/Z, 212207/Z/18/Z]
- Wellcome Trust [109144/Z/15/Z, 212207/Z/18/Z] Funding Source: Wellcome Trust
- MRC [MR/L007177/1] Funding Source: UKRI
Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.
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