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Decoding the Notch signal

期刊

DEVELOPMENT GROWTH & DIFFERENTIATION
卷 62, 期 1, 页码 4-14

出版社

WILEY
DOI: 10.1111/dgd.12644

关键词

gene regulation; Notch; signalling; transcription

资金

  1. Medical Research Council [MR/L007177/1]
  2. Wellcome Trust [109144/Z/15/Z, 212207/Z/18/Z]
  3. Wellcome Trust [109144/Z/15/Z, 212207/Z/18/Z] Funding Source: Wellcome Trust
  4. MRC [MR/L007177/1] Funding Source: UKRI

向作者/读者索取更多资源

Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.

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