期刊
DENTAL MATERIALS
卷 36, 期 1, 页码 157-166出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dental.2019.11.016
关键词
Isosorbide-derived biomonomer; Experimental biopolymer; Estrogenicity; Cytocompatibility; Bisphenol free
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2018R1D1A1B07042920, 2019R1C1C1002490]
- Global Research Development Center Program [2018K1A4A3A01064257]
- Ministry of Education (Priority Research Center Program) [2019R1A6A1A11034536]
- Dankook University
- National Research Foundation of Korea [2018R1D1A1B07042920] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Objective. Although bisphenol A-glycidyl methacrylate (Bis-GMA)-based dental materials are widely used in dentistry, Estrogenicity from released bisphenol A remains a concern due to possibility of adversely affecting the growth of children and homeostasis of adults. Here, a new family of isosorbide-derived biomonomers were synthesized and experimentally utilized as a matrix of dental sealants to provide physico-mechanical and biological properties comparable to those of a conventional Bis-GMA-based material but without the the potential estrogenicity. Methods. After synthesis of isosorbide-derived biomonomers (ISDB) by light polymerization, an experimental dental sealant with different silica filler concentrations (0-15 wt%) was characterized and compared to a commercially available Bis-GMA-based sealant. Cytotoxicity and estrogenicity assays were conducted with human oral keratinocytes and estrogen-sensitive MCF-7 cells, respectively. Results. ISDB-based dental sealants exhibited typical initially smooth surfaces with depth of cure, Vickers hardness, compressive strength/modulus, water resorption/solubility, and flowability comparable to those of the commercial sealant and met the ISO standard for dental sealants and polymer-based restorative materials. Indirect cytotoxicity tests using an extract showed comparable viability among experimental ISDB-based materials and a commercial Bis-GMA-incorporated control. DNA synthesis in MCF-7 cells (a marker of estrogenicity) and the release of bisphenol A under enzymatic incubation were not detected in ISDB-based materials. Significance. In conclusion, the comparable physico-mechanical properties of ISDB-based materials with their cytocompatibility and lack of estrogenicity suggest the potential usefulness of ISDBs as a newly developed and safe biomaterial. (C) 2019 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.
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