期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 20, 期 10, 页码 815-834出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026620666200303123102
关键词
EGFR; HER-1; ERBB-1; Tyrosine kinase; EGF; TGF-alpha; mAbs; Inhibitors; cancer
资金
- Deanship of Scientific Research and Graduate Studies at Al-Zaytoonah University of Jordan
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
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