期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 21, 期 7, 页码 713-724出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203721666200124143145
关键词
PRMT; arginine methylation; substrate specificity; PRMT molecular recognition; arginine methylome; target recognition
资金
- National Science Foundation [CHE-1412405]
Protein arginine methylation is a widespread eukaryotic posttranslational modification that occurs with as much frequency as ubiquitinylation. Yet, bow the nine different human protein arginine methyltransferases (PRMTs) recognize their respective protein targets is not well understood. This review summarizes the progress that has been made over the last decade or more to resolve this significant biochemical question. A multipronged approach involving structural biology, substrate profiling, bioorthogonal chemistry and proteomics is discussed.
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