期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 21, 期 8, 页码 777-784出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203721666191231145901
关键词
Medium-chain fatty acids (MCFAs); microbiota; gut barrier; inflammation; IBD; SOAs
资金
- National Key R&D Program of China [2018YFD0500601, 2017YFD0500501]
- National Natural Science Foundation of China [31829004, 31722054]
- College of Animal Science and Technology Young Talents Program at China Agricultural University [2017DKA001]
- Beijing Nova Programme Interdisciplinary Cooperation Project [xxj c201804]
- 111 Project [B16044]
- Developmental Fund for Animal Science - Shenzhen Jinxinnong Feed Co., Ltd.
Medium-chain fatty acids (MCFAs) are the main form of Medium Chain Triglycerides (MCTs) utilized by monogastric animals. MCFAs can be directly absorbed and supply rapid energy to promote the renewal and repair of intestinal epithelial cells, maintain the integrity of intestinal mucosal barrier function, and reduce inflammation and stress. In our review, we pay more attention to the role of MCFAs on intestinal microbiota and mucosa immunity to explore MCFA's positive effect. It was found that MCFAs and their esterified forms can decrease pathogens while increasing probiotics. In addition, being recognized via specific receptors, MCFAs are capable of alleviating inflammation to a certain extent by regulating inflammation and immune-related pathways. MCFAs may also have a certain value to relieve intestinal allergy and inflammatory bowel disease (IBD). Unknown mechanism of various MCFA characteristics still causes dilemmas in the application, thus MCFAs are used generally in limited dosages and combined with short-chain organic acids (SOAs) to attain ideal results. We hope that further studies will provide guidance for the practical use of MCFAs in animal feed.
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