期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 59, 期 -, 页码 47-53出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.02.004
关键词
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资金
- NIH [CA74305]
- Kwanjeong Educational Foundation
Akt1-3 (Akt) are a subset of the AGC protein Ser/Thr kinase family and play important roles in cell growth, metabolic regulation, cancer, and other diseases. We describe some of the roles of Akt in cell signaling and the biochemical and structural mechanisms of the regulation of Akt catalysis by the phospholipid PIP3 and by phosphorylation. Recent findings highlight a diverse set of strategies to control Akt catalytic activity to ensure its normal biological functions.
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