期刊
CURRENT OPINION IN MICROBIOLOGY
卷 52, 期 -, 页码 110-115出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2019.06.003
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资金
- Sao Paulo Research Foundation Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/50717-1, 2016/19815-2, 2016/03273-6, 2017/23933-3]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [307587/2014-2, 406351/2018-0]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/23933-3] Funding Source: FAPESP
The outcome of Leishmania infection depends on the parasite species arid the host immune response. Virulence factors have been extensively studied over the years in an effort to find efficient vaccines and/or treatments for Leishmania infection. Arginase activity in Leishmania has been described as an essential player for the polyamines pathway, impacting parasite replication and infectivity. Considering previous studies showing that the absence of arginase activity leads to low infectivity of Leishmania amazonensis, we reanalyzed transcriptomic data comparing both promastigotes and axenic amastigotes from L. amazonensis wild type (La-WT) and L. amazonensis arginase knockout (La-arg) backgrounds. The analysis produced a new compilation of modulated transcripts that indicated the role of arginase not only in the polyamines pathway but also in the modulation of virulence factors involved in parasite recognition, growth and differentiation.
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