期刊
CURRENT OPINION IN MICROBIOLOGY
卷 52, 期 -, 页码 158-164出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2019.11.001
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资金
- NC3Rs PhD studentship [NC/R001472/1]
- U.S. National Institutes of Health [K12GM119955, R01AI134636]
- Sir Henry Dale Fellowship - Wellcome Trust [211241/Z/18/Z]
- Sir Henry Dale Fellowship - Royal Society [211241/Z/18/Z]
- Wellcome Trust [211241/Z/18/Z] Funding Source: Wellcome Trust
Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy.
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