期刊
CURRENT OPINION IN IMMUNOLOGY
卷 61, 期 -, 页码 92-99出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.09.004
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类别
资金
- Rheumatology Research Foundation
- Alliance for Lupus Research
- Pfizer, Inc.
- Rosenfeld Professorship
- N.I.H. (National Institute of Arthritis and Musculoskeletal and Skin Diseases Accelerating Medicines Partnership Grant) [NIAIDR01-M-077674, 1UH2-AR-067690, NIAMSR21AR071670]
- Bertha and Louis Weinstein Research Fund
Purpose of review FDA-approved B cell-targeted therapy has expanded to a multitude of autoimmune diseases ranging from organ specific diseases, like pemphigus and multiple sclerosis, to systemic diseases such as ANCA-associated vasculitis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In this review, we discuss the variability in response to B cell-targeted therapies with a focus on the diversity of human B cells and plasma cells, and will discuss several of the promising new B cell-targeted therapies. Recent finding The pathogenic roles for B cells include autoantibody-dependent and autoantibody-independent functions whose importance may vary across diseases or even in subsets of patients with the same disease. Recent data have further demonstrated the diversity of human B cell subsets that contribute to disease as well as novel pathways of B cell activation in autoimmune disease. The importance of eliminating autoreactive B cells and plasma cells will be discussed, as well as new approaches to do so. Summary The past several years has witnessed significant advances in our knowledge of human B cell subsets and function. This has created a nuanced picture of the diverse ways B cells contribute to autoimmunity and an ever-expanding armamentarium of B cell-targeted therapies.
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