期刊
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
卷 48, 期 -, 页码 1-17出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.cocis.2020.02.001
关键词
Hydrogels; Drug delivery; Supramolecular gels; Controlled release; Smart gels; Microneedles; 3D printing
Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small molecules or colloids. They constitute a versatile platform for drug delivery because of their capacity to encapsulate and protect drugs and provide sustained and/or remotely programmable spatial and temporal release and have thus generated a substantial amount of research for the delivery of either small active compounds or biopharmaceuticals. This article discusses the features that make hydrogels attractive as matrices for delivery and reviews a range of designs, focussing on studies from recent years, in particular: 'smart' hydrogels (responding to temperature, light, magnetic fields, ultrasounds or combined stimuli); recent technologies: 3D printing and microneedles; and closes by discussing polymer-free drug delivery systems: peptides, small molecules and colloids.
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