期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 54, 期 -, 页码 63-69出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.11.005
关键词
Genetically encoded biosensor; Kinase activity reporters; Kinome
资金
- National Institutes of Health [NIH/NCI T32 CA009523, R01 MH111516, R35 CA197622, R01 DK073368, R01 GM111665]
- University of California President's Postdoctoral Fellowship
- Air Force Office of Scientific Research [FA9500-18-1-0051]
Genetically encoded fluorescent protein-based kinase biosensors are a central tool for illumination of the kinome. The adaptability and versatility of biosensors have allowed for spatiotemporal observation of real-time kinase activity in living cells and organisms. In this review, we highlight various types of kinase biosensors, along with their burgeoning applications in complex biological systems. Specifically, we focus on kinase activity reporters used in neuronal systems and whole animal settings. Genetically encoded kinase biosensors are key for elucidation of the spatiotemporal regulation of protein kinases, with broader applications beyond the Petri dish.
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