期刊
CURRENT OPINION IN CELL BIOLOGY
卷 61, 期 -, 页码 16-23出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.06.003
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资金
- French Foundation for Medical Research (FRM) grant [EQU201903007821]
- French National Research Agency (ANR) [ANR-15-CE13-0013-01]
- Canceropole Ile-de-France [2015-2-APD-01-ICR-1]
- Ligue against cancer [RS19/75-101]
- Paris Sciences et Lettres (PSL* Research University)
- Labex DEEP ANR [11-LBX-0044]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE13-0013] Funding Source: Agence Nationale de la Recherche (ANR)
During development, stem cells give rise to specialised cell types in a tightly regulated, spatiotemporal manner to drive the formation of complex three-dimensional tissues. While mechanistic insights into the gene regulatory pathways that guide cell fate choices are emerging, how morphogenetic changes are coordinated with cell fate specification remains a fundamental question in organogenesis and adult tissue homeostasis. The requirement of cell contacts for Notch signalling makes it a central pathway capable of linking dynamic cellular rearrangements during tissue morphogenesis with stem cell function. Here, we highlight recent studies that support a critical role for the Notch pathway in translating microenvironmental cues into cell fate decisions, guiding the development of diverse organ systems.
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