期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 61, 期 -, 页码 60-65出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.10.006
关键词
-
资金
- ERC [616449]
- H2020 project [760331]
- BBSRC iCASE
- Quebec Government's research funding body FRQNT
- European Research Council (ERC) [616449] Funding Source: European Research Council (ERC)
Molecular farming increasingly uses the tobacco relative Nicotiana benthamiana for production of recombinant proteins through transient expression. Several proteins are produced efficiently with this expression platform, but yields for other proteins are often very low. These low yields are frequently due to endogenous proteases. The latest genome annotations indicate that N. benthamiana encodes for at least 1243 putative proteases that probably act redundantly and consecutively on substrates in different subcellular compartments. Here, we discuss the N. benthamiana protease repertoire that may affect recombinant protein production and recent advances in protease depletion strategies to increase recombinant protein production in N. benthamiana.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据