相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The effect of cannabinoid receptor 1 blockade on adipokine and proinflammatory cytokine concentration in adipose and hepatic tissue in mice with nonalcoholic fatty liver disease
Bojan Jorgacevic et al.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2019)
Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis
Priya Handa et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2019)
Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells
Kathryn Miranda et al.
FRONTIERS IN IMMUNOLOGY (2019)
High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue
Eline N. Kuipers et al.
FRONTIERS IN PHYSIOLOGY (2019)
Peripheral modulation of the endocannabinoid system in metabolic disease
Nirajan Shrestha et al.
DRUG DISCOVERY TODAY (2018)
Serum Levels of Endocannabinoids are Independently Associated with Nonalcoholic Fatty Liver Disease
Shira Zelber-Sagi et al.
OBESITY (2017)
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Marjolein Soethoudt et al.
NATURE COMMUNICATIONS (2017)
Inverse association of marijuana use with nonalcoholic fatty liver disease among adults in the United States
Donghee Kim et al.
PLOS ONE (2017)
Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity
Pegah Mehrpouya-Bahrami et al.
SCIENTIFIC REPORTS (2017)
The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
Bojan Jorgacevic et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2017)
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation
Toshiaki Nakano et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Adipose tissue macrophages: going off track during obesity
Lily Boutens et al.
DIABETOLOGIA (2016)
Modulation of cellular redox homeostasis by the endocannabinoid system
Christopher Lipina et al.
OPEN BIOLOGY (2016)
Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease
Robert B. Laprairie et al.
MOLECULAR PHARMACOLOGY (2016)
Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease
Bojan JorgaIevic et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Oxidative stress and autophagy: Crucial modulators of kidney injury
Angara Sureshbabu et al.
REDOX BIOLOGY (2015)
Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation
Shinya U. Amano et al.
CELL METABOLISM (2014)
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease
B. Jorgacevic et al.
HUMAN & EXPERIMENTAL TOXICOLOGY (2014)
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
Pengpeng Bi et al.
NATURE MEDICINE (2014)
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
P. Jeffrey Conn et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Conference on 'PUFA mediators: implications for human health' Symposium 3: Cannabinoids in human health Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications
Roger G. Pertwee
PROCEEDINGS OF THE NUTRITION SOCIETY (2014)
The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders
Cristoforo Silvestri et al.
CELL METABOLISM (2013)
Modulating the endocannabinoid system in human health and disease successes and failures
Pal Pacher et al.
FEBS JOURNAL (2013)
Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice
Larysa V. Yuzefovych et al.
PLOS ONE (2013)
Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor
Neil T. Burford et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The role of endocannabinoids system in fatty liver disease and therapeutic potentials
Khalid A. Alswat
SAUDI JOURNAL OF GASTROENTEROLOGY (2013)
Safety of antiobesity drugs
Bernard Man Yung Cheung et al.
THERAPEUTIC ADVANCES IN DRUG SAFETY (2013)
Biased signalling and allosteric machines: new vistas and challenges for drug discovery
Terry P. Kenakin
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Blockade of Cannabinoid Receptor 1 Improves Insulin Resistance, Lipid Metabolism, and Diabetic Nephropathy in db/db Mice
D. H. Nam et al.
ENDOCRINOLOGY (2012)
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
Anabela P. Rolo et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and Gi Protein-independent ERK1/2 Kinase Activation
Kwang H. Ahn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
Francisco Javier Bermudez-Silva et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2012)
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
Haixia Xu et al.
NATURE IMMUNOLOGY (2012)
The Notch signalling system: recent insights into the complexity of a conserved pathway
K. G. Guruharsha et al.
NATURE REVIEWS GENETICS (2012)
Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis
Umbreen Ahmed et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2012)
Transcriptional Profile of Genes Involved in Oxidative Stress and Antioxidant Defense in a Dietary Murine Model of Steatohepatitis
Agnieszka Gornicka et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
The case for peripheral CB1 receptor blockade in the treatment of visceral obesity and its cardiometabolic complications
George Kunos et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Altered endocannabinoid signalling after a high-fat diet in Apoe-/- mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance
A. Bartelt et al.
DIABETOLOGIA (2011)
Acute endotoxemia following transjugular intrahepatic stent-shunt insertion is associated with systemic and cerebral vasodilatation with increased whole body nitric oxide production in critically ill cirrhotic patients
R. Jalan et al.
JOURNAL OF HEPATOLOGY (2011)
CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model
Partha Mukhopadhyay et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
Partha Mukhopadhyay et al.
CARDIOVASCULAR RESEARCH (2010)
Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs
V. Marzo et al.
CURRENT MEDICINAL CHEMISTRY (2010)
CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice
Tony Jourdan et al.
DIABETES (2010)
Inducible Nitric Oxide Distribution in the Fatty Liver of a Mouse with High Fat Diet-Induced Obesity
Seung-Kwon Ha et al.
EXPERIMENTAL ANIMALS (2010)
Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-γ
Bani Mukhopadhyay et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Signal transduction of the CB1 cannabinoid receptor
Gabor Turu et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2010)
Ligand- and Heterodimer-Directed Signaling of the CB1 Cannabinoid Receptor
Brian D. Hudson et al.
MOLECULAR PHARMACOLOGY (2010)
Endocannabinoid System Participates in Neuroendocrine Control of Homeostasis
Andrea De Laurentiis et al.
NEUROIMMUNOMODULATION (2010)
The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?
F. J. Bermudez-Silva et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2010)
The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
Roberto Vettor et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
P. Jeffrey Conn et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
Anna Wieckowska et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)
Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis
Laurie D. DeLeve et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
Won-il Jeong et al.
CELL METABOLISM (2008)
Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review
Ivana Svizenska et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2008)
CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS
Dimitris Skokos et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis - Implications for the pathogenesis of human nonalcoholic steatohepatitis
Kohji Otogawa et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Free radicals and antioxidants in normal physiological functions and human disease
Marian Valko et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
Andre J. Scheen et al.
LANCET (2006)
Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia
Isabel Matias et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
The pharmacology of cannabinoid receptors and their ligands: an overview
RG Pertwee
INTERNATIONAL JOURNAL OF OBESITY (2006)
Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients - RIO-North America: A randomized controlled trial
F Pi-Sunyer et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
JP Despres et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Allosteric modulation of the cannabinoid CB1 receptor
MR Price et al.
MOLECULAR PHARMACOLOGY (2005)
Endocannabinoid control of food intake and energy balance
V Di Marzo et al.
NATURE NEUROSCIENCE (2005)
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients:: 1-year experience from the RIO-Europe study
LF Van Gaal et al.
LANCET (2005)
Glutathione metabolism and its implications for health
GY Wu et al.
JOURNAL OF NUTRITION (2004)
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
D Amsen et al.
CELL (2004)