期刊
CURRENT MEDICINAL CHEMISTRY
卷 27, 期 28, 页码 4720-4740出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867327666200102120652
关键词
Multitarget drugs; Alzheimer's disease; Parkinson's disease; cancer; neglected tropical diseases; pharmacokinetic parameters
资金
- National Natural Science Foundation of China [21574072, 21675091, 21874078, 51703107]
- Taishan Young Scholar Program of Shandong Province [tsqn20161027]
- Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
- Natural Science Foundation of Shandong Province [ZR2017BB047]
- Project of Shandong Province Higher Educational Science and Technology Program [J15LC20]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry [20111568]
- People's Livelihood Science and Technology Project of Qingdao [166257nsh, 173378nsh]
- Innovation Leader Project of Qingdao [168325zhc]
- Postdoctoral Scientific Research Foundation of Qingdao
- First Class Discipline Project of Shandong Province
Multi-target drugs have gained considerable attention in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer side effects. Therefore, more attention is being paid to developing drugs that work on multiple targets at the same time, but developing such drugs is a huge challenge for medicinal chemists. Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters. Multi-target drugs, which have long been known and effectively used in clinical practice, are briefly discussed in the present article. In addition, in this review, we will discuss the possible applications of multi-target ligands to guide the repositioning of prospective drugs.
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