期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 58, 期 -, 页码 11-17出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2016.05.007
关键词
T cells; Natural T regulatory cells; Inflammation; Gene expression; High risk; Mood disorder; Bipolar disorder
资金
- MOODINFLAME (early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system), FP7-HEALTH [222963]
- SEVENTH FRAMEWORK PROGRAM (Advanced Immuno-neuro-endocrine Diagnostics in Psychiatry), FP7-PEOPLE [286334]
- Stanley Medical Research Institute
- Netherlands Organization for Scientific Research (NWO)
Objectives: T cell abnormalities have been repeatedly reported in adult patients with mood disorders, suggesting a role of these cells in the pathogenesis of these disorders. In the present study, we explored the dynamics of circulating T cell subsets over time in a population at high familial risk for developing a mood disorder. Methods: Children of a parent with bipolar disorder (bipolar offspring, N = 140) were assessed at three time-points: adolescence, young adulthood and adulthood. We carried out a detailed fluorescence activated cell sorting (FACS) analysis to determine various T cell subsets from frozen stored peripheral blood mononuclear cells of bipolar offspring and age- and gender-matched healthy controls at each time-point. Results: Throughout the period of observation reduced levels of CD3+ and CD3+ CD4+ T cells were observed. In bipolar offspring T(h)1, T(h)2, T(h)17 and natural T regulatory cells (T-regs) followed a dynamic course over time with reduced levels of T, in adolescence and a reduced relative number of T(h)1, T(h)17 cells in young adulthood. In post hoc analysis T-regs were inversely associated with the pro inflammatory monocyte state determined previously (r(s)=-0.220, p = 0.001). Significant associations between T cell subset abnormalities and psychopathology such as mood disorders were not found. Conclusions: A subtle partial T cell defect was present in bipolar offspring from adolescence through adulthood. Within this defect the dynamic change of inflammatory and regulatory T cell subsets suggests a high inflammatory state during adolescence, a reduced inflammatory state during young adulthood and a virtually normalized state at adulthood. (C) 2016 Elsevier Inc. All rights reserved.
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