期刊
CURRENT BIOLOGY
卷 30, 期 3, 页码 367-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2019.11.043
关键词
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资金
- Francis Crick Institute from Cancer Research UK [FC001002]
- UK Medical Research Council [FC001002]
- Wellcome Trust [FC001002, 103741/Z/14/Z]
- Wellcome Trust [103741/Z/14/Z] Funding Source: Wellcome Trust
Membrane function is fundamental to life. Each species explores membrane lipid diversity within a genetically predefined range of possibilities. How membrane lipid composition in turn defines the functional space available for evolution of membrane-centered processes remains largely unknown. We address this fundamental question using related fission yeasts Schizosaccharo-myces pombe and Schizosaccharo-myces japonicus. We show that, unlike S. pombe that generates membranes where both glycerophospholipid acyl tails are predominantly 16-18 carbons long, S. japonicus synthesizes unusual asymmetrical glycerophospholipids where the tails differ in length by 6-8 carbons. This results in stiffer bilayers with distinct lipid packing properties. Retroengineered S. pombe synthesizing the S.-japonicus-type phospholipids exhibits unfolded protein response and downregulates secretion. Importantly, our protein sequence comparisons and domain swap experiments support the hypothesis that transmembrane helices co-evolve with membranes, suggesting that, on the evolutionary scale, changes in membrane lipid composition may necessitate extensive adaptation of the membrane-associated proteome.
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