期刊
CRITICAL REVIEWS IN BIOTECHNOLOGY
卷 40, 期 2, 页码 265-281出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07388551.2019.1711015
关键词
Chinese hamster ovary (CHO); kinetic modeling; cell culture; therapeutic protein; scale-up
As a host for therapeutic protein expression, Chinese hamster ovary (CHO) cells are widely utilized in the mainstream biopharmaceutical industry. Cell culture process development plays an important role in transitioning laboratory research to manufacturing. Among different mathematic tools, kinetic modeling is commonly achieved through analyzing cell culture data to design process parameters, optimize media, and scale up bioreactors. In this review, we examine key factors for upstream process development, and summarize currently used kinetic modeling strategies. In addition, two original examples of kinetic modeling application optimizing cell culture performance are presented. A comprehensive understanding is provided for the kinetic modeling and its applications in cell culture process development.
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