期刊
CRITICAL CARE CLINICS
卷 36, 期 2, 页码 201-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2019.12.003
关键词
Angiopoietin; Tie2; Sepsis; ARDS; Vascular leakage; Coagulation; VE-PTP
资金
- National Institutes of Health [R01 HL125275, R35 HL139424]
Lethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts into overt disseminated intravascular coagulation. Disruption of an endothelial signaling axis, the Angiopoietin-Tie2 pathway, may mediate the abrupt transition from microvascular integrity to pathologic disruption. This review summarizes preclinical and clinical results that implicate the Tie2 pathway as a promising target to restore microvascular health in sepsis and ARDS.
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